Join the Jones Lab

We are always looking for talented individuals to join our multidisciplinary team. See below for currently available positions or send us your CV and cover letter.

The members of the Jones Lab have put together a Lab Manual, which can give you an idea of the type of group we are and the work environment you can expect if you decide to join us - Click Here to see the Jones Lab Manual

We are always looking for self-funded PhDs and post-docs to undertake exciting research topics in polymer antivirals, viral vector-based gene therapy, vaccine stabilisation and medical textiles. Research experience in areas such as organic chemistry, virology, and polymer synthesis are beneficial. Please send us your CV and cover letter or alternatively apply directly through the University of Manchester. 

NIR Light-triggered delivery of viral vectors for gene therapies - self-funded project

This project looks to develop a platform technology that utilises external stimuli, such as light for the triggered polymer un-coating of viral vectors for in-vivo targeted delivery. We will utilise NIR light to cause un-coating of polymer coated viral vectors. This could revolutionise the way in which we treat damaged tissue in-vivo by, for example, allowing for targeted modifications that lead to regeneration of damaged cardiac tissue, neurons, or muscle cells in-situ. 
Applications of gene therapies have become common place. Typically viral vectors are used ex-vivo for this genetic modification, on account of their excellent nuclear transfer efficiencies, broad tissue tropism and low pathogenicity. Viral vectors have struggled to find use in in-vivo applications as they have been shown to illicit an immune response and are typically sequestered in the liver. Polymer coating can be used to overcome both of these problems whilst also improving circulation times. However, polymer coating completely inhibits the ability of the viral vectors to infect. If it existed, a simple method to remove this polymer coat at the intended in-vivo site would significantly improve in-vivo gene therapies.

This project looks to develop a platform technology that utilises light-cleavable linkages between viral vectors and polymers to allow for NIR light-triggered un-coating of the polymer shell. Once developed, this platform technology can then be utilised with a wide range of viral vectors for the repair of a wide range of cells, tissues and/or organs.